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This distinction matters clinically: preserved muscle maintains resting metabolic rate, improves body composition aesthetics, and supports long-term weight stability by preventing the metabolic adaptation that often follows muscle loss

Higgins J, Deeks J, Altman D (2011) Chapter 16: Special topics in statistics

10.1177/0194599811427519 57 FreedmanM

Other Reasons GLP-1s Might Make You Feel Cold Beyond brown fat and BMR changes, there are a few more subtle (and often overlooked) reasons why GLP-1 meds can leave you reaching for a hoodie in summer: Muscle loss : Muscle mass helps generate heat