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As a triple agonist targeting GLP-1, GIP, and glucagon receptors, it provides a unique framework for studying multi-receptor metabolic modulation

Chronic stress and poor sleep elevate cortisol chronically, which can partially counteract the appetite-suppressing effects of GLP-1 therapy

Beyond contributing to the conceptual knowledge of appetite and energy balance regulation in humans [12], we also made potentially clinically important discoveries, such as why dietary protein provides greater immediate satiety than the other macronutrients and why milk is more satiating than sugar-sweetened soft drinks (both dietary exposures increase GLP-1 relative to their comparators) [13]

This depends on how NICE assesses retatrutides cost-effectiveness against Mounjaro