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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

Chen et al., 1999

Concentrated fractions were then incubated with 20mM GSSG (Thermo J63715.06) and PMab1 Fv-clasp at a 1:1.5 molar ratio for 30 min at room temperature

Every vial ships with an HPLC purity trace (most of the time 99%), mass-spec identity confirmation, and endotoxin/heavy-metal screening on the batch