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WES can be considered a powerful genetic tool with great potential to address diverse phenotypes as they arise, with an efficient turnaround time at the request of both, patients and physicians

As pioneered by Murray and co-workers 33 , surface functionalization of AuNCs, in particular their functionalization through ligand-exchange strategy 34 , grants them high versatility, while selective functionality is incorporated onto the ligand-protected NCs by exchanging the surface protecting ligand with desired molecules containing appropriate functional groups

Similarly, senescent cells induce DR5 and its ligand TRAIL, being primed to die via extrinsic apoptosis, a fate prevented by cFLIP induction 26