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Researchers generally refer to oxidative stress when one or more parameters reflecting the balance of free radical processes are disturbed, leading to an increase in the steady-state level of ROS that affects many vital processes

10.1194/jlr.R075481 J

Mechanism difference Semaglutide (GLP-1 agonist): appetite regulation, satiety, improved glycemic control (New England Journal of Medicine) Tirzepatide (GLP-1/GIP agonist): broader incretin effects, robust appetite/weight effects (New England Journal of Medicine) AOD-9604: targeted fat-metabolism signaling

In the specific context of hearing and tinnitus, a conceptual link exists in the proposed brain-ear-heart axis, where neurotrophic factor supplementation to the cochlea could inhibit pathological protein aggregation and support neuronal health, potentially preventing conditions like AD and associated amyloid cardiomyopathy (Shityakov et al., 2021)