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One key action of IL-10 is to transform macrophages of an M1 inflammatory phenotype that produce high levels of pro-inflammatory cytokines and low levels of anti-inflammatory cytokines, to an M2b regulatory phenotype that produce low levels of pro-inflammatory cytokines and high levels of anti-inflammatory molecules [1, 26]

Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all- trans retinoic acid in acute promyelocytic leukemia

When natural IGF-1 binds to IGFBPs, it's temporarily inactive