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Discover LPL-01: How This Fits Into a Larger Canine Longevity System Aging in dogs is not driven by a single pathway

A decrease in cardiac output leads to the secretion of Renin, which then catalyses the formation of angiotensin I (Ang I) from its precursor Angiotensinogen

2d and Extended Data Fig

This conversion can either occur by binding to external ligands (outside-in signaling) or by interaction of the cytoplasmic domains of integrin chains with intracellular signaling cascades triggered by foreign antigens, chemokines or proinflammatory cytokines (inside-out signaling) 4