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Regular physical activity, tailored to your fitness level, can paradoxically improve energy levels and reduce feelings of fatigue

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A plausible explanation of this apparent dichotomy is that p53 promotes cell survival by preventing excessive increases in ROS under moderate oxidative stress, whereas when the oxygen species increase over a threshold level, it switches to becoming a ROS inducer, triggering cell death

Other than in STEP 2, which enrolled patients with type 2 diabetes, patients with a hemoglobin A1C of 6.5% or greater were excluded, as were patients who had a self-reported change in body weight of greater than 5 kg within 90 days of screening