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It binds to Toll-like receptor 4 (TLR4) on immune cells, triggering a massive, systemic release of pro-inflammatory cytokines, including Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-alpha)

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Both are used in gut health research contexts

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ARA-290 Explored for its role in cellular protection, tissue response, and recovery-focused research models

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