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To summarize these mechanisms and their corresponding efficacy with GLP-1RAs or GLP-1, GLP-1RAs show the endothelial protective properties and thus owe to modulating vascular tone and maintaining endothelial barrier integrity, as well as the anti-adhesive and anti-thrombotic actions

Theyre not magic potions but are pretty close

Several factors influence the degree of weight regain after discontinuation: Biological factors : Your body's metabolic adaptation during weight loss includes decreased energy expenditure and increased hunger hormones (such as ghrelin), which persist after stopping medication

Leiter, R.E