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Several factors influence metabolic rate, including age, sex, body composition, genetics, and hormonal status

As G q -recruiting and G-protein coupled receptors (GPCR), the downstream signaling pathways of GLP-1Rs and GIPRs parallel those of insulin and lead to the induction of the neuroprotective phosphoinositide 3-Kinase (PI3K)/Akt (also known as protein kinase B)/mammalian target of rapamycin (mTor), cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP-response element binding protein (CREB) as well as Raf/mitogen-activated protein kinase (MEK) 1/2 /extracellular signal-regulated kinase (ERK) pathways (for the GLP-1R pathways, see also Figure 1

Vitamin C: 100 mg