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BG11 medium, like CTT, does not contain any carbohydrates that could act as substrates for transglycosylase-like enzymes

Such effects are consistent with their established reduction in atherosclerotic cardiovascular events and may be particularly relevant in patients with obesity, insulin resistance, or HFpEF phenotypes, and taken together, these mechanistic differences provide a biologically plausible rationale for combination therapy: SGLT2 inhibitors primarily target HF-related hemodynamic and cardiorenal pathways, whereas GLP-1 receptor agonists may further improve metabolic and vascular risk

Persistent anxiety beyond 14 days warrants stopping the protocol

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