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Researchers investigate peptide-mediated communication involving vascular endothelial growth factor (VEGF) , endothelial signaling proteins, nitric oxide-associated pathways, extracellular matrix proteins, and molecular regulatory mechanisms to better understand coordinated cellular signaling within experimental systems

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These modified GLP-1 analogues showed a marginal reduction in receptor affinity (2- to 5-fold), except des-amino-GLP-1 that lost binding by 15-fold