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doi: 10.1111/j.1365-2230.2012.04441.x

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Naringenin alleviates renal ischemia reperfusion injury by suppressing ER stress-induced pyroptosis and apoptosis through activating Nrf2/HO-1 signaling pathway

These approaches achieve therapeutic effects through intersecting mechanisms such as restoration of the microbial ecological balance, normalization of microbiota-derived metabolite profiles, and amelioration of gut barrier dysfunction, which contributes to systemic inflammation