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For example, if a patient maintains stable weight reduction for a year but then loses more weight after 6 months on the same GLP-1RA dose, secondary causes should be investigated, especially due to a higher malignancy risk in patients with obesity

While the original announcement of the MFN deals with Eli Lilly and Novo Nordisk noted Medicaid programs would also have access to the $245 price available to Medicare, the final negotiated discounted price available to state Medicaid programs mentioned in the state Medicaid RFA is not available to the public, only participating states

Furthermore, in a meta-analysis study, a moderate increase in the relative risk and a slight increase in absolute risk of thyroid cancer with the use of GLP-1 agonists was reported 48

Triple-Hormone-Receptor Agonist GLP-3 R for Obesity - A Phase 2 Trial