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The use of XIGDUO XR for this indication is also supported by evidence from adequate and well-controlled trials of metformin HCl immediate-release tablets in adults with additional data from a controlled clinical trial using metformin HCl immediate-release tablets in pediatric patients 10 to 16 years old with type 2 diabetes mellitus, and pharmacokinetic data with metformin HCl extended-release tablets in adults [see Clinical Pharmacology (12.3) and Clinical Studies (14.1, 14.2)]

The cardiovascular outcomes trial SUSTAIN-6, published in the New England Journal of Medicine, demonstrated cardiovascular safety in a population where many participants were receiving antiplatelet therapy

ADAs 2026 Standards are expanding the relevance of GLP-1-based therapies in diabetes, obesity, and related metabolic care

By following a balanced diet and lifestyle, you can support the natural release of GLP-1