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The above insights are being tested in a clinical trial (NCT04107311) that aims to prospectively investigate the role of the intestinal microbiome and autoimmune panels as predictors of Grade 2 irAEs requiring immunosuppression

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In laboratory and pre-clinical research settings, glutathione is studied across virtually every area of cellular biology owing to its central, non-redundant role in redox homeostasis and its interactions with dozens of enzyme systems, signalling pathways, and disease-relevant biological processes