Key points: Both medications cause similar gastrointestinal side effects, most commonly nausea, diarrhoea, and constipation In the head-to-head trial, liraglutide had double the discontinuation rate of semaglutide (27.6% vs 13.5%) Side effects tend to occur early in treatment and improve over time Wegovy has cardiovascular outcome data (SELECT trial) that liraglutide does not Dosing and practical differences Injection frequency One of the most significant practical differences is how often you inject
But when you look at a thousand studies, and then you try it out, and then you understand some metabolic pathways, and you hypothesize, and then you test, and you look at the results, the name for that is science
Fluorodeoxyglucose-PET imaging shows characteristic hypo-metabolism in the posterior cingulate cortex and precuneus in the early stages of Alzheimer's disease, with temporoparietal hypo-metabolism manifesting before structural changes [160]
You may recognize it under the brand name Xenical, which has been on the market since 1998
