PLEASE NOTE: Clinical trials have indicated that Retatrutide may lead to greater average weight loss than tirzepatide, another dual-agonist medication, although retatrutide is still investigational and not yet FDA-approved
Medical conditions that reduce response Several conditions can blunt semaglutide effectiveness regardless of whether it is compounded or brand-name: Hypothyroidism , especially untreated or undertreated, slows metabolism and counteracts weight loss Insulin resistance and type 2 diabetes can require higher doses for the same effect PCOS creates hormonal resistance to weight loss interventions Cushing syndrome and other cortisol disorders override appetite suppression mechanisms Certain medications , including some antidepressants, antipsychotics, corticosteroids, and beta-blockers, promote weight gain through independent pathways If you have any of these conditions, semaglutide may still work but could require higher doses or additional interventions

To see if semaglutide is right for you, you can join one of Sesames health programs for weight loss or diabetes to connect with a licensed clinician, see if treatment is appropriate, and get ongoing support to help you stay on track with your goals
This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer