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Preclinical studies have shown that semaglutide attenuates DR progression by ameliorating retinal vasculopathy and oxidative stress in both in vivo and in vitro models, likely through mechanisms involving reduced inflammation and apoptosis [70, 71]

In a Bank of America note published on Monday, the analyst argues that brand mail pharmacy margins can be 5-10% (and in many cases pharmacies are losing money on GLP-1 scripts), which are significantly lower than the 50% gross margins we estimate HIMS is capturing in its GLP-1 portfolio. It is unlikely that HIMS will follow Ros lead to partner with brand manufacturers, the analyst added, because HIMS differentiation and success is tied to its own brand equity for its products and selling branded pharmaceutical drugs would both hurt margins and cannibalize its core products. Diversifying Beyond the Major GLP-1 Drugs Hims could also look to broaden its weight loss offerings, leveraging its established telehealth platform to incorporate non-drug-based solutions