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The effects of DPP-4 on bone health are underscored by its effects in generating proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), contributing to inflammatory processes mediated by adipose tissue macrophages, which are implicated in conditions ranging from obesity to osteoporosis [21]

This finding is consistent with the view that these organelles have evolved as part of the need of early eukaryotes to defend against oxygen, which is germane to the role of G6PD today

Chronic exposure to pollutants, heavy metals, and endocrine-disrupting chemicals, as well as lifestyle habits such as smoking, an ultra-processed diet, and chronic stress, leads to redox imbalance in both oocytes and the ovarian microenvironment

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