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In another RDP clinical study, 156 osteoarthritis patients, took 100 mg Pycnogenol day or placebo for three months ( -supplemented subjects and by 11% in placebo-controlled patients

Common Side Effects Mild nausea (most common, usually improves within a few weeks) Diarrhea or constipation due to slowed digestion Bloating or fullness after meals Mild headaches or fatigue Less Common But Serious Side Effects Pancreatitis (rare) Watch for persistent, severe abdominal pain. Hypoglycemia (rare in non-diabetics) Can occur when combined with insulin therapy. Allergic reactions (very rare) Monitor for rash, swelling, or difficulty breathing

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