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This work lays a solid foundation for the development of sequential therapeutic agents that target vascular repair and provides robust scientific evidence to optimize strategies for the prevention and treatment of tissue injury across various contexts

Background In sections XIV

For instance, NAD + levels and mitochondrial function have been shown to decline in sarcopenia muscle in one cohort 249 , while another study did not observe a difference in NAD + levels in sarcopenic muscle, and even NR supplementation had no effect on NAD + levels 262