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When allowed to accumulate in the body, these free radicals can damage nucleic acid bases, the side chains of amino acids in proteins, and unsaturated lipids

STEP-1 Trial (NEJM, 2021): 1,961 adults with BMI 30 (or 27 with a weight-related condition)

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Cardiac Protection MGF and the Heart The MGF E-domain peptide has been shown to increase proliferation and migration of mesenchymal bone marrow-derived stem cells and to stimulate pro-angiogenic activity in human vascular endothelial cells mechanisms directly relevant to myocardial repair following ischaemic injury