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Tirzepatide is generally not appropriate for people who are pregnant, planning pregnancy, or breastfeeding, or for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2

The muscle-sparing data is still maturing, the question of how much of the dramatic weight loss is fat versus lean tissue is being answered in real time, and the answers will inevitably show patient-to-patient variability that the trial means cannot capture