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While no clinical trials have directly compared Wegovy vs phentermine, available evidence from separate trials suggests that Wegovy leads to more weight loss than phentermine
Sermorelin's FDA Journey: Approved, Discontinued, and Compounded Sermorelin acetate (Geref) was FDA-approved in 1997 for pediatric GHD 1 and in 1990 for diagnostic use.26 The manufacturer discontinued Geref in 2008 due to "manufacturing difficulties," not safety or efficacy concerns.12 In 2013, the FDA confirmed it wasn't withdrawn for safety/effectiveness, allowing for potential generic approvals.12 Currently, Sermorelin is primarily available as a compounded medication 3, which is permitted but not individually FDA-approved like mass-produced drugs.22 5.2
Phlebotomy frequency Because of the scarcity of data points on phlebotomies with concurrent SGLT-2 inhibitor exposure, SGLT2 inhibitor use was not considered in the analyses of the temporal distance between two successive phlebotomies
An oral version could dramatically improve patient adherence and widen its use, making it a more convenient option for diabetes management
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