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Research and Regulatory Status Approved Use (Native IGF-1): The native recombinant human IGF-1 (Mecasermin) is FDA-approved for growth failure in children with severe IGF-1 deficiency

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Independent studies also found that several ISGs were overexpressed in islets from T1D and AAb+ patients compared to controls, following an expression pattern similar to that of islets exposed to CVB (149, 172, 173)