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The rationale: once hepatic steatosis resolves and dietary methyl intake stabilizes, endogenous methylation capacity can maintain phosphatidylcholine synthesis without weekly exogenous supplementation

Type 2 diabetes (though it's not yet approved for this use) : In the phase 3 ACHIEVE-1 trial, adults with early type 2 diabetes who took orforglipron experienced a drop in their A1C from 8% to 6.5%6.7% after 40 weeks

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