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When glutathione neutralizes a free radical, it becomes "oxidized" or inactive

Indeed, melatonin is highly permeable to cell membranes and easily crosses the bloodbrain barrier 51 , ensuring a good therapeutic profile for brain diseases, and is also able to accumulate into mitochondria, probably via GLUT/SLC2A and PEPT1/2 carriers 52,53

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for intramyocellular and extramyocellular lipids (IMCL and EMCL), creatine (Cr), components containing trimethylamine (TMA) group, and acetyl-carnitine detection (water non-suppressed spectra with TE = 280 ms, TR = 2 s and number of transients = 64) [45,46,47]