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In particular, microglia exposed to MIA exhibit blunted responsiveness to inflammatory stimuli, accompanied by epigenetic reprogramming including changes in chromatin accessibility and reduced transcription factor occupancy at open chromatin regions (Hayes et al., 2022)

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The Significance of the ACHIEVE-1 trial ACHIEVE-1 is the first of seven Phase 3 trials in Eli Lillys clinical program for orforglipron, which seeks to offer an effective oral alternative to injectable GLP-1 weight loss injections for treating type 2 diabetes and obesity