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Likewise, the suppressor oncogene p53 is capable of suppressing the activity of the IGF-1R promoter as well as lowering the endogenous levels of IGF-1R mRNA (Werner et al, 2000)

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In contrast with adaptive immunity, which encompasses antigen-specific responses by T and B lymphocytes, trained immunity is characterized by antigen non-specific tissue adaptation to acute and chronic inflammation, sometimes in response to infection, and has been predominantly studied in professional innate immune cells such as macrophages, monocytes, dendritic cells and natural killer cells 23,24,25