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Structurally, the brain is highly susceptible to oxidative stress due to its high lipids composition and elevated oxygen composition

This study documents a positive association between frequency of MTHFR -C677T and MTHFR -A1298C polymorphisms and latitude, with increases in latitude significantly associated with increased frequency of the polymorphic allele of these variants

It has also been studied for its potential to improve chronic conditions and overall resilience