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In women with PCOS, hyperandrogenism, insulin resistance, and adipose-derived inflammatory cues have been associated with altered neutrophil activation profiles, including increased oxidative stress, degranulation, and markers suggestive of neutrophil extracellular trap (NET) formation
Methylfolate is required in the activation of tetrahydrobiopterin (i.e., BH4), which is a necessary cofactor for both tryptophan hydroxylase and tyrosine hydroxylase, enzymes required in the synthesis of serotonin and norepinephrine/dopamine, respectively (Figure 1)
Increased cycle regularity can in turn lead to improved fertility, making it easier for some people with PCOS to conceive
Each pathway plays a unique role in the effects that researchers are observing during experiments and trials: GABAergic System Modulation: DSIP affects GABA receptors in the brain, altering GABAergic signalling patterns
