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As a result, achieving meaningful systemic exposure through oral administration often requires significant formulation innovation

Patients with HFpEF were defined as follows: 1) patients with symptoms and signs of HF as defined by the Framingham criteria, 2) patients with a left ventricular ejection fraction 45% as previously described (6) (7), and 3) patients without HF aetiologies of severe valve disease, congenital disease, complete atrial ventricular block, sick sinus syndrome, pericardial disease, primary pulmonary hypertension, pulmonary artery embolism, and acute myocardial infarction

When losses exceed intake, supplementation may be necessary (Holmes et al