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In additional experiments, treatment of DIO rats with GEP12 at 10 nmol/kg/day resulted in significant reductions in food intake and body weight (food intake: mean difference 41.3 kcal/day, 95% CI 62.8 to 19.9 kcal/day, p = 0.0019

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Taken together, these patterns were compelling enough that major research groups began formally studying GLP-1 medications in alcohol use disorder and other addictions

Eat a balanced diet that includes fruits & vegetables, whole grains, fiber, healthy fats, smaller portions and no sugary drinks Aim to stop eating when you feel full instead of cleaning your plate each time Practice mindful eating compared to eating in front of a TV or while on a phone Talk to your doctor about an exercise routine that makes sense for your health At least 150 minutes of moderate-intensity physical activity per week is recommended Your doctor may start you with a more simple routine like taking walks once a day Instead of being critical about your weight, encourage any healthy behaviors and the things you are doing right Helpful Programs These programs can help you manage your weight