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In the periphery, as an instant progression from the central disturbance, a multiorgan failure syndrome appeared, comparable to the deadly syndromes induced by the peripheral vessels occlusion, the suprahepatic occlusion of the inferior caval vein (BuddChiari syndrome) or Pringle maneuver ischemia, reperfusion (i.e., heart, lung, liver, kidney, gastrointestinal lesions and thrombosis progression) [26,27]

The anti-proliferative impact of pCS on renal cells surpasses that of other uremic toxins (e.g., indoxyl sulfate, IS), potentially accelerating kidney disease progression via pro-fibrotic signaling pathway activation (29)

TKT, as part of the cytosolic pentose phosphate pathway, along with the mitochondrial multienzyme complexes of pyruvate (PDHC) and 2-oxoglutarate dehydrogenases (OGDHC), are essential for energy production from glucose oxidation

2009 documented similar timelines in their photoaged-skin RCT 10