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Since the beginning of renal replacement therapy for end stage renal disease (ESRD) through dialysis or transplantation, the number of patients treated for terminal kidney failure worldwide has continued to grow at an annual rate of approximately 7%

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According to Dr Aravinda, congenital diseases include Immerslund-Grsbeck illness, which causes severe vitamin B12 insufficiency, and genetic intrinsic factor abnormalities which can both lead to severe vitamin B12 deficiency