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The UK Summary of Product Characteristics (SmPC) for semaglutide, liraglutide and tirzepatide specifically states they should not be used during breast-feeding due to lack of human data
At the same time these astrocytes reduce expression of several key homoeostatic proteins such as glutamate transporters, glutamine synthetase, K ir 4.1 inward rectifying channels involved in K + buffering, and connexion 43 responsible for syncytial coupling
GLP-1 receptor agonists seem to have the unique ability to reduce these effects without completely blocking dopamine release
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