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Understanding a patients full metabolic risk profile including insulin sensitivity, inflammatory markers, hormonal status, and body composition enables our physicians to develop a genuinely personalised strategy for disease prevention, of which GLP-1 therapy may form an important component
Their metabolic actions include enhanced peripheral glucose uptake, reduced hepatic glucose output, and improved lipid metabolism [11]
Data from the Phase 2 programme (NEJM, 2023) provide an initial picture of its tolerability, which broadly mirrors that of other incretin-based therapies, with some additional considerations related to its glucagon receptor activity
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