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In excitotoxicity glutamate triggers the rise of intracellular Ca 2+ levels, followed by up regulation of nNOS, dysfunction of mitochondria, ROS production, ER stress, and release of lysosomal enzymes

There are several uric acid transporters, however, the major urate transporter is URAT1 (encoded by the SLC22A12 gene) located in the apical membrane of proximal tubule epithelial cells

Glutathione can contribute to anti-aging efforts by reducing oxidative stress and inflammation, which are factors in the aging process

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