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Clinical Research Findings: SUSTAIN and PIONEER Trials A comprehensive safety analysis of 11,159 patients with type 2 diabetes across the SUSTAIN and PIONEER phase IIIa clinical trial programs found that gastrointestinal disorders occurred in 41.9% of patients receiving subcutaneous semaglutide and 39.1% receiving oral semaglutide, compared to 22.0% and 24.8% in comparator groups, respectively

firstly demonstrates the utility of a novel metabolic agent, GLP-1, in attenuating myocardial stunning after ischemiareperfusion in canine models [97]

Brodin EE, Braekkan SK, Vik A, Brox J, Hansen JB

Additional lawsuits and adverse event reports have described bowel obstruction, ileus, gallbladder disease, gallstones, cyclic vomiting syndrome, and vision-related complications involving optic nerve damage and sudden vision loss