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Involving numerous immune and non-immune cell types as well as associated cytokines, growth factors, and extracellular components in a healthy, acute response orderly wound healing consists of the four consecutive stages of haemostasis, inflammation, proliferation, and tissue remodelling 1,2

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This is specifically manifested by increased mitochondrial DNA content, upregulation of related gene expression, improvement of the oxidative metabolism, and elevation of the expression levels of key proteins involved in oxidative phosphorylation [26]