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It has a docking effect with Src homology 2 signal molecules in cells, transferring the signal through Src homology 3 to Son of Sevenless, phosphorylating downstream Ras molecules, thereby activating the extracellular signal-related kinases (ERK1/2) pathway and regulating the growth, proliferation, and differentiation of osteoblasts [26, 27]

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Based on the STEP 1 clinical trial, patients lost approximately 2% of body weight per month for the first six months, slowing to about 1% per month thereafter, reaching an average of ~1516% total body weight loss by week 68