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JAMA (2012) 308(11):112231

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chronic/high-dose use) Renal: fluid retention, acute kidney injury Hypersensitivity: rash, bronchospasm in asthma patients Precautions / Contraindications History of peptic ulcer disease or GI bleeding Renal impairment, heart failure Third trimester of pregnancy risk of premature ductus arteriosus closure Avoid combination with other NSAIDs unless directed NSAID inhibits COX prostaglandins Common side effect: GI irritation / ulcer Cardiovascular risk with chronic use Used for pain, fever, inflammation, dysmenorrhea OTC dosing: up to 1,200 mg/day