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Ultra-high resolution structures can provide an unparalleled level of detail, showing individual atoms and their arrangement within the protein molecule, capturing the dynamic nature of proteins and showing their regions with multiple conformations, as well as allowing evaluation of hydrogen bonding and solvent networks

It should not be treated as a universal fix for every peptide, because some peptides may be unstable in acidic conditions or may require a different solvent system

Avoid freezing solutions unless the manufacturer's guidance allows freezing safely

And people can experience an array of complications