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Effect size guidelines, sample size calculations, and statistical power in gerontology

In the DURATION program for type 2 diabetes: DURATION-1 : Exenatide ER (Bydureon) 2 mg weekly produced 3.7 kg weight loss over 30 weeks DURATION-5 : Bydureon produced 2.3 kg weight loss over 24 weeks Three-year data : Sustained weight reduction of approximately 2.3 kg (5.1 lbs) from baseline Exenatide is not FDA-approved for chronic weight management

64 Runx1 directly binds to the upstream regulatory region of the PU.1 gene, regulating its expression during embryonic and adult hematopoiesis

Clinical data, realworld use, and patient needs shape how each drug fits into a weight loss treatment plan