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16 However, other evidence supports the notion that DRG are a component of the peripheral nervous system

By interrupting a key proteinprotein interaction that allows senescent cells to persist, FOXO4-DRI offers the potential to selectively eliminate those cells and thus improve tissue function, reduce inflammation, and restore aspects of youthful physiology

Dysfunctional hypothalamic function can be seen in ME/CFS patients in the form of up-regulation of hypothalamic 5-hydroxytryptamine (5-HT) receptors (441) and abnormal arginine/vasopressin responses to deprivation tests and water loading (440)

This step is often the most challenging, emotionally taxing, and financially burdensome part of the journey, but functional medicine practitioners universally agree it is non-negotiable