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Left, in the inactive conformation, the top of the transmembrane domain is stabilized by interactions of the ECD with the TM6ECL3TM7 region

Peer review Peer review information Nature Reviews Drug Discovery thanks Timo Mller and the other anonymous reviewer/s for their contribution to the peer review of this manuscript

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Relevant studies have found that exendin-4 could mediate the neuroprotective effect on -aminobutyric acid neurons in the piriform cortex and striatum and play a neuroprotective role in a cAMP/PKA- and PI3K/AKT-dependent manner after stroke (84, 85)