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The fact that low vitamin D levels in obese individuals may further exacerbate venous dysfunction by impairing nitric oxide bioavailability and increasing oxidative stress has been reported in the literature [17, 38, 44], but no studies investigated, to the best of our knowledge, the NOS isoforms local expression in the varicose veins

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The conversion of folic acid to its active form, 5-MTHF (5-methyltetrahydrofolate), can be inefficient in individuals with MTHFR polymorphisms [2]