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Clinical implications of targeting intestinal BTRs That BTR signaling is functionally linked to the secretion of hormones integral to the regulation of energy intake and glycemia, as well as the control of gastric emptying, has stimulated substantial interest in targeting this pathway for the management of obesity and type 2 diabetes (publications from clinical studies are summarized in Table 3)

The goal is not a dramatic before-and-after

persistent dietary patterns, physical activity, and metabolic-context modulation aim to attenuate rebound once pharmacological pressure is reduced